ABSTRACT
ntroduction: Vitiligo is an apparent skin condition that has a psychological impact on the affected individuals and their families. Its prevalence is estimated to be about (0.5-2%) globally. Misunderstandings, and negative attitudes toward vitiligo patients are the most important factors affecting the quality of life of vitiligo patients. Objective:The objective of this study was to identify the common misconceptions and attitudes about the nature, causes and prognosis of vitiligoin Al-Baha region, Saudi Arabia. Methods:A cross sectional study collected data from the general population in the public malls in Al-Baha region, Saudi Arabia. We used a questionnaire which was developed by the authors, the questionnaire included questions regarding vitiligo cause, nature, prognosis and the attitude toward vitiligo Results:A total of (453) responses were analysed, of which (53%) were females, and (90.9%) were Saudis. Theparticipants’ ages ranged from (16 -64) with a mean of (28.3). The majority of our sample had a high level of education; university (65.1%), High school (26%) and less than high school (6%). Our population believed that gecko and its saliva were the commonest cause (38.1%). Most of the respondents (44.4%) thought that the condition is exaggerated by stress and anxiety. Regarding attitude; (31.5%) are unwilling to marry a vitiligo patient. Conclusion:The results of the present study show that the misconceptions and attitudes toward vitiligo are prevalent. Health awareness campaigns should be implanted to educate the people and improve the quality of life of the affected individuals
ABSTRACT
Background: Since the introduction of oxaliplatin and irinotecan, they have been the mainstay chemotherapies in the fluorouracil-based regimens, FOLFOX, FOLFIRI, and FOLFOXIRI, used in the treatment of advanced and/or metastatic colorectal cancer (CRC). These regimens are effective and usually well-tolerated in patients. However, they have been associated with neutropenia in some patients. Objective: The aim of this study was to assess risk factors of chemotherapy-induced neutropenia associated with the regimens used in CRC patients. Methods: A retrospective analysis was conducted of all CRC patients’ records who had been treated with the aforementioned regimens between January 2016 and February 2019 at the oncology clinics in a tertiary referral hospital in Riyadh, Saudi Arabia. Results: A total of 136 patients treated with the standard CRC regimens were identified. The majority of CRC patients (63.2%) had stage IV with extensive metastases. Twenty-two patients (16.2%) had developed neutropenia. However, only 13 of the neutropenic patients (59.1%) had shown symptoms of infections or fever. Most neutropenia occurred between the third and the fourth cycle of the used regimen. A significant increase in neutropenia was found in females (p=0.0273) and in patients with stage IV (p=0.0378). However, 53 CRC patients (39.0%) who received filgrastim had shown a significantly lower incidence of neutropenia (p=0.0027). Conclusion: Despite the effectiveness of the CRC chemotherapy regimens, the risk of neutropenia is still considerably elevated. The use of granulocyte colonystimulating factors such as filgrastim is an effective intervention to reduce neutropenia, hence infections, in high-risk CRC patients
ABSTRACT
Glenohumeral bone defects are a typical finding in shoulder dislocation and they are intensely connected with the reappearance of dislocation and failure following arthroscopic Bankart repair. Advanced imaging assessment should subsequently be performed in order to recognize, quantify and portray the bone defects. Despite the fact that magnetic resonance has significant value in the appraisal of the glenoid labrum and rotator cuff, computed tomography scan is the examination of choice for studying bone defects. The imaging methodology selected for shoulder dislocation relies upon its accessibility and the treatment plan for a specific patient. Radiography is economical and is promptly accessible. It ought to be executed as the underlying imaging examination in patients giving a clinical issue identified with the shoulder. It complements the other advanced methods and gives an outline of the bony components of the shoulder joint. In few patients, radiography obviates additional imaging